Atomic Force Microscopy analyses of Polycaprolactone/Alendronate systems intended to produce biomaterials

Authors

  • Talita Goulart da Silva Universidade Federal Rural do Rio de Janeiro – Instituto de Tecnologia – Departamento de Engenharia Química – Rio de Janeiro (RJ), Brasil. , Universidade Federal Rural do Rio de Janeiro – Instituto de Tecnologia – Departamento de Engenharia Química – Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0001-8170-5528 (unauthenticated)
  • Cristiane Evelise Ribeiro da Silva Instituto Nacional de Tecnologia – Divisão de Ensaios em Materiais e Produtos – Rio de Janeiro (RJ), Brasil. , Instituto Nacional de Tecnologia – Divisão de Ensaios em Materiais e Produtos – Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0003-4855-2579 (unauthenticated)
  • Yasmin Garcia dos Anjos Universidade Federal Rural do Rio de Janeiro – Instituto de Tecnologia – Departamento de Engenharia Química – Rio de Janeiro (RJ), Brasil. , Universidade Federal Rural do Rio de Janeiro – Instituto de Tecnologia – Departamento de Engenharia Química – Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0002-9898-2553 (unauthenticated)
  • Roberta Helena Mendonça Universidade Federal Rural do Rio de Janeiro – Instituto de Tecnologia – Departamento de Engenharia Química – Rio de Janeiro (RJ), Brasil. , Universidade Federal Rural do Rio de Janeiro – Instituto de Tecnologia – Departamento de Engenharia Química – Rio de Janeiro (RJ), Brasil. https://orcid.org/0000-0003-1034-7027 (unauthenticated)

DOI:

https://doi.org/10.17563/rbav.v42i1.1234

Abstract

The development of biomaterials such as scaffolds, films, membranes and others has attracted attention. Polymeric materials play an essential role in producing biomaterials for bone tissue regeneration, however, selecting materials within this context is still a significant challenge, especially for osteoporotic bones. Composite
powders based on polycaprolactone (PCL) and sodium alendronate bisphosphonate (ALE) were recently applied to biomaterials development by solvent casting, compression molding, additive manufacturing, and other
techniques. ALE is widely used in osteoporosis treatment and presents some side effects when administered
orally or intravenously. Combining ALE with polymers to produce controlled drug-release systems is a promising
alternative for mitigating these side effects. Hence, this work aims to evaluate, by atomic force microscopy, the morphology of films obtained using the system in powder form (PCL/ALE). Thus, films were produced by solvent
casting using chloroform and PCL_ALE (0.2 g of ALE: 1.5 g of PCL). Compression molding was also applied to have films using PCL/ALE (2.0 MPa; 100 °C). The films were characterized using SEM and AFM analysis. The AFM
analysis showed that the technique affected the films' morphology and may be an important tool for selecting
appropriate production methods for future applications in bone regeneration.

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Published

2023-05-12

Issue

Vol. 42 No. 1 (2023)

Section

Original Paper

License

Copyright (c) 2023 Talita Goulart da Silva , Cristiane Evelise Ribeiro da Silva, Yasmin Garcia dos Anjos, Roberta Helena Mendonça

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.